Masteron will significantly suppress natural testosterone production making exogenous testosterone therapy important when using this steroid. Failure to include exogenous testosterone will lead most men to a low testosterone condition, which not only comes with numerous possible symptoms but is also extremely unhealthy.
As most will use Masteron in a cutting cycle, it’s very common not to want to use a lot of testosterone due to the high levels of estrogenic activity it can provide. If this is the case, you will find a low dose of 100-200mg per week of testosterone to be enough to combat suppression and give you the needed testosterone.
Once Masteron is discontinued and all exogenous steroidal hormones have cleared your system, natural testosterone production will begin again. Prior levels will not return to normal over night, this will take several months. Due to the slow recovery, Post Cycle Therapy (PCT) plans are often recommended. This will speed up the recovery greatly; however, it won’t bring your levels back to their peak, this will still take time. A PCT plan will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise and significantly cut down on the total recovery time. This natural recovery does assume no prior low testosterone condition existed. It also assumes no damage was done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) through improper supplementation practices.
A couple of years ago I was suffering from what my allergist called chronic idiopathic urticaria and angioedema. His solution was a prescription of antihistamines, which kept them at bay initially. Eventually, though, I’d get breakthrough hives and swelling. When I suggested checking for gut dysbiosis since we were dealing with an immune reaction and I knew that 70% of your immune system is in the gut, he just dismissed the idea, saying there was no cure for my problem, that it would eventually go away and just double down on the antihistamines to keep the problem under control. Not being satisfied with that answer (actually, I called him a shill for the pharmaceutical industry), I went and found a functional medicine doctor who, after a bunch of tests, determined that, indeed, I was suffering from gut dysbiosis. She put me on an elimination diet to limit my intake of foods that would contribute to the dysbiosis, and gave me some suppliments to rid me of the overgrowth of certain bugs and finally had me take probiotics to repopulate my gut with the right bacteria. Once we completed the treatment regimen, the hives and facial swelling stopped and I haven’t had another case since.
In animal toxicity studies, minor serum biochemical alterations in ALT, glucose, phosphorus and triglycerides were observed which were transient in nature. The signs of toxicity in animals were increased excretion of saliva, gastro-intestinal symptoms, loose stools and ion imbalance. These occurred at dosages which provided>17-fold the systemic exposure seen at the clinical dosage. In monkeys, the adverse effects appeared at doses from 150 mg/kg/day (>232-fold the systemic exposure seen at the clinical dose). In animal studies, montelukast did not affect fertility or reproductive performance at systemic exposure exceeding the clinical systemic exposure by greater than 24-fold. A slight decrease in pup body weight was noted in the female fertility study in rats at 200 mg/kg/day (>69fold the clinical systemic exposure). In studies in rabbits, a higher incidence of incomplete ossification, compared with concurrent control animals, was seen at systemic exposure>24-fold the clinical systemic exposure seen at the clinical dose. No abnormalities were seen in rats. Montelukast has been shown to cross the placental barrier and is excreted in breast milk of animals.