Doxycycline (Vibramycin) is the antibiotic of choice for adults and children. Doxycycline is contraindicated in pregnant women, although it may be considered in life-threatening situations when clinical suspicion of tick-borne illness is high. The recommended dosage of doxycycline is 100 mg orally or intravenously twice a day for adults, and mg per kg orally or intravenously twice a day for children who weigh less than 100 lb ( kg). Although the optimal duration of therapy has not been established, a five- to seven-day course is recommended for RMSF and HME after the fever subsides. A 10- to 14-day course is recommended for HGA. Chloramphenicol (Chloromycetin) may be used as an alternative to doxycycline; however, this drug may cause side effects, and monitoring of blood indices may be needed.
It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.